Genetically informed single-cell and spatial mapping of metabolic programs in human health and disease
Heng Xu, Guangrui Huang, Linpeng Zhang, Wenbin Liu, Qixing Wu, Minshuo Chen, Dongdong Zhao, Yaqi Zhang, Anlong Xu
The paper introduces gmMAP, a framework that integrates metabolite GWAS with single-cell and spatial transcriptomes to map metabolic programs at cellular and spatial resolution, revealing associations between exogenous metabolites and cellular states.
bioRxiv · Jun 30, 2026 · PreprintGenomics