A W Xu

This study identifies a non-canonical pyroptosis pathway in cartilaginous fish involving GSDMA/B cleavage by LPS-activated caspase-1, revealing dual-fragment regulation and antimicrobial activity.

The paper introduces gmMAP, a framework that integrates metabolite GWAS with single-cell and spatial transcriptomes to map metabolic programs at cellular and spatial resolution, revealing associations between exogenous metabolites and cellular states.

The paper uses saturation genome editing to assess the functional impact of RAD51D and XRCC2 variants, showing high accuracy in distinguishing pathogenic from benign variants.

This study identifies IFN homologs in jawless vertebrates and demonstrates their antiviral function, tracing the evolutionary origin of IFN to basal chordates.

The paper shows that reduced m6A in alveolar macrophages after influenza enhances trained immunity, improving antibacterial function and protecting against secondary infections.