APE1 Coordinates Its Disordered Region and Metal Cofactors to Drive Genome Surveillance
Donghun Lee, S S Kim, Gyeongpil Jo, Juwon Kim, Jungmin Yoo, Jejoong Yoo, Ja Yil Lee, Gwangrog Lee
This study reveals how APE1 uses structural disorder and metal-ion coordination to enable long-range DNA lesion recognition through a sliding-based search strategy.
Nucleic Acids Research · May 1, 2026Peer-reviewedMolecular Biology