Trans-ancestry genome-wide association meta-analysis of antidepressant response to selective serotonin reuptake inhibitors in clinical studies of depression
Ke Hu, Chris Wai Hang Lo, Swapnil Awasthi, Oliver Pain, Madhurbain Singh, Yeeun Ahn, Katherine Jean Aitchison, Bernhard Theodor Baune, Joanna M. Biernacka, Guido Bondolfi, Tania Carrillo‐Roa, Hong Choi, Darina Czamara, Katharina Domschke, Chiara Fabbri, , Cathryn M. Lewis
This study performs a trans-ancestry GWAS of SSRI response in depression, finding suggestive associations and enrichment in serotonergic pathways but no genome-wide significant variants.
medRxiv · Jun 4, 2026 · PreprintGenetic & Genomic Medicine