Bernhard Theodor Baune

This study performs a trans-ancestry GWAS of SSRI response in depression, finding suggestive associations and enrichment in serotonergic pathways but no genome-wide significant variants.

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

This paper develops a multi-trait polygenic score (mt-PGS) to predict lithium responsiveness in bipolar disorder, finding it improves prediction accuracy compared to single-trait methods.

This study identifies genetic subtypes of major depressive symptoms by analyzing data from clinical and community cohorts, finding distinct factors for appetite/weight symptoms and missing data patterns.

This paper develops a transcriptome-based polygenic risk score (T-PRS) linking depression-related cortical gene expression changes to brain morphology and symptom severity in MDD.

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

This paper examines brain aging in major depressive disorder (MDD) using a large dataset, finding that MDD patients show increased brain age differences compared to controls.

This study identifies subcortical shape differences in MDD patients using ENIGMA data, highlighting region-specific changes in surface area and thickness.

This study finds that higher HbA1c levels are associated with worse cognitive performance and reduced white matter integrity in healthy young adults.

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.

A meta-analysis of 807,553 people from 23andMe, UK Biobank and PGC finds 102 depression variants. 87 of them replicate in 1,306,354 individuals, and heritability is enriched in prefrontal brain regions.

The paper develops deep learning models to assess the quality of subcortical brain shape models from MRI, reducing human rater time by 46-70%.

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.

This paper reviews genetic overlaps between mood disorders and cardio-metabolic diseases, identifying 24 shared genes and pathways involved in both conditions.

This study investigates whether polygenic risk scores (PRS) can predict antidepressant response in MDD, finding no significant predictive effect.