Darina Czamara

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

The paper examines how prenatal social disadvantage and psychosocial stress affect DNA methylation in children and their potential role in psychopathology.

This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

This study performs a trans-ancestry GWAS of SSRI response in depression, finding suggestive associations and enrichment in serotonergic pathways but no genome-wide significant variants.

The paper identifies contmeQTLs linking childhood adversity to epigenetic changes in immune cells, which are associated with disease risk and inflammatory profiles.

The paper examines developmental correlates of epigenetic and polygenic indices of cognition and education from birth to young adulthood, finding Epigenetic-g is plastic in early childhood and captures distinct variation from polygenic indices.

The paper describes the curation and initial analysis of molecular genetic and epigenetic data from the TwinLife study, highlighting associations between polygenic scores and attrition, and stability of epigenetic clocks in saliva.

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

This study investigates how early life stress affects brain function and behavior in mice, revealing sex-specific differences in neurobiological outcomes.

RAMEN dissects gene-environment contributions to DNA methylome variability in cord blood, finding genetics explains the largest proportion of DNAme variance.

This study identifies 77 genetic loci associated with suicidality through genome-wide association analyses across multiple cohorts and provides biological insights into its genetic architecture.

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

This study examines differences between Infinium MethylationEPIC v1 and v2, showing high array-level concordance but probe-level variation, and recommends accounting for version differences in analyses.

This study examines genetic and environmental influences on epigenetic aging variance across adolescence and young adulthood using twin data and four aging estimators.

The paper examines FKBP5 DNA methylation in schizophrenia and finds lower methylation in a proximal enhancer linked to higher gene expression and age.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

This study shows glucocorticoids increase specific basal progenitors via ZBTB16, leading to more neurons and linking to educational attainment and brain structure.

This study uses longitudinal meta-regression to examine how DNA methylation effects on child health outcomes vary by timing, finding larger effects in childhood but noisier associations and time-specific signals.

This study examines DNA methylation at birth and its association with childhood cognitive skills, finding weak single CpG site associations and one region near DUSP22 linked to non-verbal cognition.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

The paper investigates how psychiatric disease and aging affect FKBP5 expression in the human brain, identifying supragranular neurons as key targets.

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

The paper investigates how glucocorticoid receptor activation affects neuronal development in fetal human brain organoids using single-cell transcriptomics, finding cell-type specific impacts on differentiation and behavior-related gene expression.

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

This study investigates genetic associations between major depression and cardio-metabolic traits, finding shared genetic aetiology regardless of depression onset age.

The paper conducts a GWAS to identify genetic variants associated with a cognitive predictor of dyslexia, finding significant associations with variants near MIR924HG and NKAIN3.