Comprehensive statistical inference of the clonal structure of cancer from multiple biopsies
Jie Liu, John T. Halloran, Jeffrey A. Bilmes, Riza M. Daza, Choli Lee, Elisabeth M. Mahen, Donna E. Prunkard, Chao-Zhong Song, Sibel H. Blau, Michael O. Dorschner, Vijayakrishna K. Gadi, Jay Shendure, C. Anthony Blau, William Stafford Noble
This paper introduces THEMIS, a method for analyzing tumor heterogeneity across multiple biopsies, showing improved accuracy over existing methods and applications in tracking cancer progression and treatment resistance.
Scientific Reports · Nov 29, 2017Peer-reviewedBioinformatics