ACUTE AMYLOID-B 40 EXPOSURE DISRUPTS METABOLIC INSULIN SIGNALING IN BLOOD-BRAIN BARRIER ENDOTHELIAL CELLS
Douglas B. Nelson, Krishna R. Kalari, Karunya K. Kandimalla
This study shows that Aβ40 exposure disrupts insulin signaling in BBB endothelial cells by reducing Akt phosphorylation and altering AMPK activity.
bioRxiv · Nov 21, 2025 · PreprintMolecular Biology