Karunya K. Kandimalla

This study investigates how metabolic syndrome in mice affects amyloid-beta and glucose transport across the blood-brain barrier, linking insulin resistance to Alzheimer's disease pathology.

This study shows butyrate reduces amyloid-beta 42 accumulation at the blood-brain barrier by activating insulin signaling pathways and improving BBB integrity.

This study shows butyrate reduces Aβ42 and TNF-α-induced VCAM-1 expression in BBB endothelial cells by modulating the STAT3/GATA6 axis.

The paper constructs a comprehensive single-nucleus RNA-seq atlas of the human neurovascular unit in Alzheimer's disease, revealing sex-specific vascular dysfunctions and disrupted intercellular communication.

This study investigates how pericyte degeneration contributes to blood-brain barrier disruption in Alzheimer's disease by examining insulin signaling and MMP/TIMP imbalance in an in vitro model.

This study shows that Aβ40 exposure disrupts insulin signaling in BBB endothelial cells by reducing Akt phosphorylation and altering AMPK activity.

This study shows TNF-alpha increases A{beta}42 accumulation in BBB endothelial cells by altering endocytosis-related proteins, linking inflammation to A{beta} pathology in Alzheimer's disease.

The paper uses digital spatial profiling to analyze transcriptomic changes in the neurovascular unit of Alzheimer's transgenic mice, identifying dysregulated signaling and potential therapeutic targets.

This study shows gut microbiota affects drug absorption and metabolism by altering gene expression and intestinal permeability in mice.

This study identifies distinct endocytic pathways for Aβ40 and Aβ42 in BBB endothelial cells, showing clathrin-mediated uptake for Aβ40 and caveolae-mediated uptake for Aβ42, with differential intracellular trafficking outcomes.

The paper analyzes insulin-responsive gene expression dynamics in BBB cells to identify molecular mechanisms linking insulin resistance to AD pathology.