Acidic pH is a Metabolic Switch for 2‐Hydroxyglutarate Generation and Signaling
Sergiy M Nadtochiy, Xenia Schafer, Dragony Fu, Keith Nehrke, Joshua Munger, Paul S Brookes
This study shows acidic pH increases 2-HG levels by enhancing its production and reducing its removal, affecting HIF signaling and oncometabolism.
bioRxiv · Jul 22, 2016Biochemistry