Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson's disease and related disorders
J. M. Flores-Fernandez, V. Pesch, A. Sriraman, E. Chimal-Juarez, S. Amidian, X. Wang, S. Reithofer, L. Ma, G. Tamgueney, H. Wille
This paper designs vaccines targeting misfolded alpha-synuclein by mimicking its fibril structure, inducing antibodies that recognize pathological forms without reacting to native protein.
bioRxiv · Jun 30, 2023Biochemistry