HDAC4 controls senescence and aging by safeguarding the epigenetic identity and ensuring the genomic integrity
E. Di Giorgio, H. Paluvai, E. Dalla, L. Ranzino, A. Renzini, V. Moresi, V. Cutano, R. Picco, C. Brancolini
This study shows HDAC4 is downregulated during senescence and aging, leading to replication stress, inflammation, and genomic instability.
bioRxiv · Jun 4, 2020 · PreprintCell Biology