E. Fernandez-de Gortari

Conserved luminal C-terminal domain dynamically controls interdomain communication in sarcolipin

This study uses molecular dynamics simulations to show that the conserved C-terminal domain of sarcolipin dynamically controls interdomain communication, essential for its regulatory function.

Structural basis for relief of the sarcoplasmic reticulum Ca2+-ATPase inhibition by phospholamban at saturating Ca2+ conditions

This study uses molecular dynamics simulations to show that Ca2+ binding at saturating concentrations relieves SERCA inhibition by phospholamban through local structural changes, without altering PLB's overall conformation.