Manipulation of a cation-{Pi} sandwich reveals conformational flexibility in phenylalanine hydroxylase
E. C. Arturo, G. Merkel, M. R. Hansen, S. Lisowski, D. Almeida, K. Gupta, E. K. Jaffe
This study shows that altering Phe80 in PAH affects its conformational equilibrium, revealing intermediates in the transition between resting and activated states.
bioRxiv · Feb 28, 2020Biochemistry