Dynamic and Facilitated Binding of Topoisomerase Accelerates Topological Relaxation
D. Michieletto, Y. A. G. Fosado, E. Melas, M. Baiesi, L. Tubiana, E. Orlandini
This study shows dynamic TopoII binding accelerates topological relaxation of DNA knots, independent of substrate length, by enhancing search efficiency through facilitated diffusion.
bioRxiv · Aug 28, 2021Biophysics