E. Orlandini

Folding kinetics of an entangled protein

This paper studies the folding kinetics of an entangled protein, finding that entanglement leads to distinct kinetic intermediates and folding pathways.

Topological Gelation of Reconnecting Polymers

This study investigates topological gelation in semiflexible polymer rings under confinement, showing that stiffness or concentration can trigger a transition from segregated to linked polymer networks.

Dynamic and Facilitated Binding of Topoisomerase Accelerates Topological Relaxation

This study shows dynamic TopoII binding accelerates topological relaxation of DNA knots, independent of substrate length, by enhancing search efficiency through facilitated diffusion.

Magnetic Polymer Models for Epigenetics-Driven Chromosome Folding

This paper uses magnetic polymer models to study how epigenetic modifications affect chromosome folding and gene expression, showing phase transitions and validating results with simulations.

Nonequilibrium Theory of Epigenomic Microphase Separation in the Cell Nucleus

The paper develops a non-equilibrium theory to explain epigenomic microphase separation in the nucleus, showing that non-equilibrium processes stabilize epigenomic domains.

Synergy of Topoisomerase and Structural-Maintenance-of Chromosomes Proteins Creates a Universal Pathway to Simplify Genome Topology

The paper identifies a synergistic mechanism between Topoisomerase and SMC proteins that simplifies genome topology by localizing entanglements, enabling efficient resolution in various cellular conditions.

Physical Principles of Retroviral Integration in the Human Genome

This study develops a biophysical model to explain retroviral integration site selection in the human genome, showing that physical factors like DNA accessibility and elasticity influence integration preferences.

Shaping Epigenetic Memory via Genomic Bookmarking

This paper introduces a biophysical model of genomic bookmarking to explain how epigenetic domains are maintained and modified through histone marks and protein interactions in Drosophila.

Epigenetic Transitions And Knotted Solitons In Stretched Chromatin

This study investigates how stretching and knotting of chromatin fibers influence epigenetic order through in silico simulations.