Role of the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway in Human β CellProliferation
C. Iorio, J. L. Rourke, L. Wells, J.-I. Sakamaki, E. Moon, Q. Hu, T. Kin, R. Screaton
This study identifies the GPR3-SIK2 pathway as a regulator of human β cell proliferation, showing that GPR3 silencing activates SIK2 to drive cell cycle entry and increase β cell mass.
bioRxiv · May 31, 2021Cell Biology