Strategies to improve scFvs as crystallization chaperones suggested by analysis of a complex with the human PHD-bromodomain SP140
M. Fairhead, C. Preger, E. Wigren, C. Strain-Damerell, E. Ossipova, M. Ye, M. Makola, N. A. Burgess-Brown, H. Persson, F. von Delft, S. Graslund
The paper uses a scFv to solve the structure of SP140's PHD-bromodomain and suggests strategies to improve scFvs as crystallization chaperones.
bioRxiv · Sep 13, 2019 · PreprintBiochemistry