Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2
P. Dvorak, D. Bednar, P. Vanacek, L. Balek, L. Eiselleova, V. Stepankova, E. Sebestova, M. Kunova Bosakova, Z. Konecna, S. Mazurenko, A. Kunka, D. Horak, R. Chaloupkova, J. Brezovky, P. Krejci, , J. Damborsky
This paper describes the engineering of a hyperstable FGF2 variant with nine mutations using a computer-assisted strategy, achieving high stability without losing biological function.
bioRxiv · Jan 15, 2017Bioengineering