Systematic analysis uncovers SYK dependency in NF1LoF melanoma cells
C. Abecunas, C. Whitehead, E. Ziemke, D. G. Baumann, C. Frankowski-McGregor, J. Sebolt-Leopold, M. Fallahi-Sichani
This study identifies SYK as a therapeutic target in NF1LoF melanoma cells, showing that MTX-216, a compound inhibiting both PI3K and SYK, effectively blocks tumor growth.
bioRxiv · Mar 6, 2022Cancer Biology