PH domain and leucine rich repeat phosphatase 1 (Phlpp1) suppresses parathyroid hormone receptor 1 (Pth1r) expression and signaling during bone growth
Samantha R. Weaver, Earnest L. Taylor, Elizabeth L. Zars, Katherine M. Arnold, Elizabeth W. Bradley, Jennifer J. Westendorf
This study shows that Phlpp1 deficiency increases Pth1r expression and signaling, leading to longer bones and thicker growth plates in mice.
Journal of Bone and Mineral Research · Dec 1, 2020Peer-reviewedMolecular Biology