Discovery of Non-Degradative Covalent Molecular Glues for Transcriptional Reprogramming
Tuong Nghi Duong, Edward Pandji, Qian Shao, Daniel K. Nomura
This study identifies ZD-1-186, a non-degradative molecular glue that rewires BCL6 proximity to suppress MYC and induce tumor-suppressive genes in lymphoma cells.
bioRxiv · Dec 14, 2025 · PreprintBiochemistry