Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification
Julia Kaye, Naufa Amirani, Úna Chan, Noura Al Bistami, Zohreh Faghihmonzavi, Monika Ahirwar, Reuben Thomas, Wesley Robinson, Edward Vertudes, Krishna Raja, Mariya Barch, Drew A. Linsley, Ana Jovičić, Steven M. Finkbeiner
This paper uses machine learning to identify cellular signatures in human motor neurons that distinguish TDP-43 ALS subtypes and enable patient stratification.
bioRxiv · Apr 24, 2026 · PreprintNeuroscience