Author

Naufa Amirani

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:imaging· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Julia KayeiD· 2 shared Mariya Barch· 2 shared Reuben ThomasiD· 2 shared Steven M. FinkbeineriD· 2 shared Zohreh Faghihmonzavi· 2 shared Ana JovičićiD· 1 shared Aziz ZafariD· 1 shared Chao HouiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Julia KayeORCID

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Author profile →

3 papers

Recent·Most cited

Molecular dynamics simulations of intrinsically disordered protein regions enable biophysical interpretation of variant effect predictors

Aziz Zafar, Chao Hou, Naufa Amirani, Yufeng Shen

The paper develops MDmis, a method using molecular dynamics simulations of intrinsically disordered regions to predict variant pathogenicity, finding Long IDRs show stronger pathogenic effects than Short IDRs.

Human Genetics and Genomics Advances · May 1, 2026Peer-reviewedBioinformatics

Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification

Julia Kaye, Naufa Amirani, Úna Chan, Noura Al Bistami, Zohreh Faghihmonzavi, Monika Ahirwar, Reuben Thomas, Wesley Robinson, Edward Vertudes, Krishna Raja, Mariya Barch, Drew A. Linsley, Ana Jovičić, Steven M. Finkbeiner

This paper uses machine learning to identify cellular signatures in human motor neurons that distinguish TDP-43 ALS subtypes and enable patient stratification.

bioRxiv · Apr 24, 2026 · PreprintNeuroscience

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons

Jennifer T. Stocksdale, Matthew Joseph Leventhal, Stephanie Lam, Yuxin Xu, Yi Wang, Keona Q. Wang, Reuben Thomas, Zohreh Faghihmonzavi, Yogindra Raghav, Charlene Smith-Geater, Jie Wu, Ricardo Miramontes, Kanchan Sarda, Heather Johnston, Min‐Gyoung Shin, , Leslie Michels Thompson

This study compares the effects of HTT knockout and CAG repeat expansion in cortical neurons, identifying shared and distinct biological pathways involved in HD.

Neurobiology of Disease · Apr 19, 2025Peer-reviewedCell Biology