Reduced myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke after imatinib treatment
Manuel Zeitelhofer, Christina Stefanitsch, Jil Protzmann, Daniel Torrente, Milena Z. Adzemovic, Sebastian A. Lewandowski, Lars Muhl, Ulf Eriksson, Ingrid Nilsson, EJ. Su, Daniel A. Lawrence, Linda Fredriksson
This study shows imatinib reduces myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke, improving functional outcomes in mice and overlapping with human stroke transcriptome data.
bioRxiv · Oct 28, 2021 · PreprintNeuroscience