Daniel A. Lawrence

This study shows that PAI-1 deficiency leads to early cardiac hemorrhage and fibrosis under hemodynamic stress, with mutations in the protease-inhibitory domain causing similar pathology.

This study identifies occludin's role as a dynein adaptor regulating vascular permeability and collateral angiogenesis through phosphorylation-dependent trafficking.

The paper identifies SorlA as a novel PAI-1 interactor required for lung fibrosis, showing SorlA deficiency protects against fibrosis in mice and SorlA is upregulated in human IPF lung tissue.

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

This study shows that thrombolysis worsens cerebrovascular injury after ischemic stroke by increasing adipose lipolysis, which can be mitigated by VEGF-B antagonism.

This study shows imatinib reduces myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke, improving functional outcomes in mice and overlapping with human stroke transcriptome data.