A Mechanistic Understanding of the Activity-Stability Trade-off in PETase
Shuang Chen, Ekram Akram, Hui Rong Liang, Weili Qiao, Yifei Zhang, Shozeb M Haider, Yufei Cao
This study investigates the activity-stability trade-off in PETase using simulations and experiments, revealing how reshaping loop dynamics can enhance both stability and activity.
Angewandte Chemie International Edition · Jul 23, 2025Peer-reviewedBiochemistry