HIV-1 Nefs are cargo-sensitive AP-1 trimerization switches in tetherin and MHC-I downregulation
Kyle L. Morris, Cosmo Z. Buffalo, Christina Martina Stürzel, Elena Heusinger, Frank Kirchhoff, Xuefeng Ren, James H. Hurley
The paper reveals how HIV-1 Nef modulates AP-1 trimerization through cargo dynamics and phosphorylation to regulate tetherin and MHC-I downregulation.
Cell · Jul 1, 2018Peer-reviewedMolecular Biology