Integrating structure-based machine learning and co-evolution to investigate specificity in plant sesquiterpene synthases
Janani Durairaj, Elena Melillo, Harro J. Bouwmeester, Jules Beekwilder, Dick de Ridder, Aalt D. J. van Dijk
The paper predicts precursor cation specificity in plant sesquiterpene synthases using machine learning and co-evolution analysis, identifying key residues for enzyme function.
PLoS Computational Biology · Mar 22, 2021Peer-reviewedBioinformatics