Nephronophthisis-associated FBW7 mediates cyst-dependent decline of renal function in ADPKD
Maulin Mukeshchandra Patel, Vasileios Gerakopoulos, Eleni Petsouki, Kurt A. Zimmerman, Leonidas Tsiokas
This study investigates the role of FBW7 in kidney function decline in NPHP and ADPKD, finding that FBW7 loss in the medulla causes fibrosis while its accumulation in the cortex links cysts to renal dysfunction.
bioRxiv · Feb 29, 2024 · PreprintGenetics