Mutagenic impact and evolutionary influence of radiotherapy in hematologic malignancies
Benjamin T. Diamond, Dhanvantri Chahar, Michael David Jain, Alexandra Maria Poos, Michael A. Durante, Bachisio Ziccheddu, Marcella Kaddoura, Marios Papadimitriou, Kylee H. Maclachlan, Tomas Jelinek, Faith E. Davies, Nicholas B. Figura, Gareth John Morgan, Elias Mai, Katja Christina Weisel, , Francesco Maura
The paper investigates the mutagenic impact of radiotherapy in hematologic malignancies and finds that RT contributes to the ID8 mutational signature, which is associated with treatment resistance and relapse.
bioRxiv · Nov 15, 2024 · PreprintGenomics