Author

Marcella Kaddoura

University of MiamiORCID 0000-0002-4529-7405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Research Focus:variant calling· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alexandra Maria PoosiD· 3 shared Bachisio ZicchedduiD· 3 shared Benjamin T. DiamondiD· 3 shared Francesco MauraiD· 3 shared Marc Steffen RaabiD· 3 shared Marios PapadimitriouiD· 3 shared Niels WeinholdiD· 3 shared Ola LandgreniD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Alexandra Maria PoosORCID

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3 papers

Recent·Most cited

Temporal Genomic Dynamics Shape Clinical Trajectory in Multiple Myeloma

Francesco Maura, Marcella Kaddoura, Alexandra Maria Poos, Linda Banovic Baughn, Bachisio Ziccheddu, Marc‐Andrea Baertsch, Anthony M. Cirrincione, Kylee H. Maclachlan, Monika Chojnacka, Benjamin T. Diamond, Marios Papadimitriou, Patrick Blaney, Lukas John, Philipp Reichert, Stefanie Huhn, , Niels Weinhold

This study analyzes whole-genome sequencing data from multiple myeloma patients to show that the timing of genetic events, not just their presence, affects clinical outcomes.

Nature Genetics · Aug 20, 2025Peer-reviewedCancer Biology

CD38 biallelic loss is a recurrent mechanism of resistance to anti-CD38 antibodies in multiple myeloma.

Benjamin T. Diamond, Linda Banovic Baughn, Mansour Poorebrahim, Alexandra Maria Poos, Holly Lee, Marcella Kaddoura, Julia Erin Wiedmeier, Michael A. Durante, Gregory E. Otteson, Dragan Jevremović, Hongwei Tang, Stefan Fröhling, Marc‐Andrea Baertsch, Marios Papadimitriou, Bachisio Ziccheddu, , Francesco Maura

This study identifies biallelic CD38 loss as a mechanism of resistance to anti-CD38 antibodies in multiple myeloma, with specific mutations affecting antibody efficacy.

Blood · Jun 10, 2025Peer-reviewedCancer Biology

Mutagenic impact and evolutionary influence of radiotherapy in hematologic malignancies

Benjamin T. Diamond, Dhanvantri Chahar, Michael David Jain, Alexandra Maria Poos, Michael A. Durante, Bachisio Ziccheddu, Marcella Kaddoura, Marios Papadimitriou, Kylee H. Maclachlan, Tomas Jelinek, Faith E. Davies, Nicholas B. Figura, Gareth John Morgan, Elias Mai, Katja Christina Weisel, , Francesco Maura

The paper investigates the mutagenic impact of radiotherapy in hematologic malignancies and finds that RT contributes to the ID8 mutational signature, which is associated with treatment resistance and relapse.

bioRxiv · Nov 15, 2024 · PreprintGenomics