Acute buprenorphine exposure depresses neonatal respiratory chemoreflexes in the presence or absence of naloxone
Michael L. Frazure, Khushi Praveen, Elias Sitzmann, Emily Gayle Flanigan, Ralph Frank Fregosi
This study shows that acute buprenorphine exposure reduces ventilation and metabolic rates in neonatal rats, with pre-treatment with naloxone mitigating these effects.
bioRxiv · May 17, 2026 · PreprintPhysiology