Isotope Dilution nanoLC-MS/MS Quantitation of Methylglyoxal DNA-Protein Crosslinks: Formation and Repair in Human Cells
Reinner O. Omondi, Elijah M. Barnes, Krishna C. Gurajala, Gabrielle Fisette, Ibaad A. Chaudray, Luke N. Erber
This paper develops a mass spectrometry method to quantify MGO-induced DNA-protein crosslinks in human cells and identifies SPRTN as a key repair enzyme.
Analytical Chemistry · Apr 17, 2026Peer-reviewedCancer Biology