Surface versus volume synthesis governs growth-dependent efficacy of a β-lactam antibiotic
Rebecca Brouwers, Leonardo Mancini, Sharareh Tavaddod, Jacob Biboy, Marco Mauri, Elizabeth Tatham, Marie-Luise Enghardt, Ariane Zander, Pietro Cicuta, Waldemar Vollmer, Rosalind J. Allen
This study shows that mecillinam affects the balance between surface area and volume synthesis in E. coli, leading to growth-rate dependent efficacy and lysis or sustained growth depending on the medium.
bioRxiv · Jan 31, 2024 · PreprintMicrobiology