MicrobiologybioRxivPreprint
Surface versus volume synthesis governs growth-dependent efficacy of a β-lactam antibiotic
Rebecca Brouwers, Leonardo Mancini, Sharareh Tavaddod…·Rosalind J. Allen
This study shows that mecillinam affects the balance between surface area and volume synthesis in E. coli, leading to growth-rate dependent efficacy and lysis or sustained growth depending on the medium.
DOI 10.1101/2024.01.31.578235