High-throughput engineering of ligand-activated splicing ribozyme through domain insertion
August O. Staubus, Ella Ramamurthy, Anika Gupta, Madison Furnish, Arjun Khakhar, James Chappell
This study engineers ligand-activated splicing ribozymes (LASRs) using domain insertion and high-throughput screening, showing their functionality across multiple kingdoms and applications in genetic regulation and information recording.
bioRxiv · May 22, 2026 · PreprintSynthetic Biology