Progranulin deficiency perturbs lipid metabolism in white matter microglia
Dahyun Yu, Ellen Armour, Sonnet S. Davis, Jung H. Suh, Matthew J. Simon, Jimei Tong, Gilbert Di Paolo, Leonard Petrucelli
This study shows that PGRN deficiency in microglia affects lipid metabolism, including reduced BMP and PE and increased GalCer, with age-dependent changes in Grn KO mice.
bioRxiv · Jul 28, 2026 · PreprintNeuroscience