Astrocyte CCN1 stabilizes neural circuits in the adult brain
Laura Sancho, Matthew Boisvert, Trinity Eddy, Jillybeth Burgado, Minerva Contreras, Lara Labarta-Bajo, Ellen Wang, Lisa Tatsumi, Nicola J. Allen
This study identifies CCN1 as an astrocyte-secreted factor that stabilizes neural circuits in the adult brain by promoting inhibitory circuit maturation and limiting plasticity.
Nature · Dec 17, 2025Peer-reviewedNeuroscience