Nicola J. Allen

This study shows suppressing BMP signaling in astrocytes reduces molecular and functional deficits in fragile X syndrome.

This study identifies CCN1 as an astrocyte-secreted factor that stabilizes neural circuits in the adult brain by promoting inhibitory circuit maturation and limiting plasticity.

This study shows that antiviral type I interferons drive astrocyte aging and motor decline in aging, with implications for therapeutic intervention.

This study identifies SEMA3C as an astrocyte-secreted protein contributing to Rett Syndrome pathology and shows its normalization rescues dendritic and behavioral deficits.

This study identifies pleiotrophin dysregulation in astrocytes as a contributor to neuronal structural and functional deficits in Down Syndrome, showing potential for therapeutic intervention.

This study identifies CK2 as a key driver of glial inflammation in neurodegenerative disorders and shows that its inhibition reduces inflammation in AD models.

This study shows astrocyte glypican 5 is necessary for synapse maturation and stabilization in the developing mouse cortex, with implications for neurological disorders.

The paper identifies glypican 5 downregulation in astrocytes as a contributor to synaptic dysfunction in Alzheimer's disease models and shows its reversal can improve cognitive function.

The paper identifies disorder-specific and shared changes in astrocyte protein secretion and gene expression in neurodevelopmental disorders, linking increased Igfbp2 and BMP signaling to altered neuronal development.

This study investigates the role of Chrdl1 in regulating spine density and recovery after ischemic stroke using Chrdl1 knockout mice.

The paper identifies astrocyte synapse-regulating genes in the developing mouse visual cortex and shows their expression is modulated by neuronal activity and calcium signaling.