Progressive muscle metabolic reprogramming in asymptomatic ALS gene mutation carriers
Céline Buon, Dimitrije Milunov, Delphine Sapaly, Timothée Lenglet, Maria del Mar Amador, Elsie Piller, Sabrina Bendris, Flore Cheguillaume, Rasha Slika, Eleni Siopi, Stéphanie Bauché, Isabelle Le Ber, François Salachas, Foudil Lamari, Anthony Béhin, , Gaëlle Bruneteau
Skeletal muscle from individuals at elevated genetic risk for ALS/FTD undergoes progressive metabolic reprogramming far before disease onset.
bioRxiv · Dec 17, 2025 · PreprintNeuroscience