Eleni Siopi

Parathyroid Hormone Receptor 1 Signaling Encodes Multifaceted Metabolic Programs in AgRP Neurons

This study identifies PTH1R signaling in AgRP neurons as a mechanism controlling feeding behavior and nutrient partitioning through distinct kinase activation and lipophagic processes.

Progressive muscle metabolic reprogramming in asymptomatic ALS gene mutation carriers

Skeletal muscle from individuals at elevated genetic risk for ALS/FTD undergoes progressive metabolic reprogramming far before disease onset.

The impact of gut microbiota on depressive-like behaviors and adult hippocampal neurogenesis requires the endocannabinoid system

This study shows that gut microbiota changes induced by chronic stress affect depressive-like behaviors and adult hippocampal neurogenesis through the endocannabinoid system in mice.

Gut microbiota requires vagus nerve integrity to promote depression

The paper shows that stress alters gut microbiota, which can induce depression and reduce neurogenesis, but this effect is blocked by vagus nerve disruption.