The calcium channel Orai1 is required for osteoblast development: studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1
Lisa J. Robinson, Jonathan Soboloff, Irina L. Tourkova, Quitterie C. Larrouture, Kelechi M. Onwuka, Dionysios J. Papachristou, Scott Gross, Robert Hooper, Elsie Samakai, Paul F. Worley, Peng Liu, Jan Peter Tuckermann, Michelle R. Witt, Harry C. Blair
This study shows that Orai1 is essential for osteoblast development by using chimeric mice with conditional deletion of Orai1 in osteoprogenitor cells, revealing impaired bone formation and mineralization.
PLoS ONE · May 11, 2023Peer-reviewedDevelopmental Biology