Physiological caffeine concentrations do not affect enteric neural crest cell migration in a mouse model
Olivier Romito, Justine Peres, Monica Dicu, Emeline Lelong, Isabelle Le Parco, Nadege Bondurand, Nicolas R Chevalier
This study shows that physiological caffeine doses do not impair enteric neural crest cell migration in a mouse model, suggesting caffeine is not directly responsible for Hirschsprung disease risk.
bioRxiv · Nov 4, 2026 · PreprintDevelopmental Biology