SpyRing-Mediated Cyclization of TEV Protease, Guided by AlphaFold, Improves Thermostability
Tadashi Nakai, Yota Nakai, Naoki Takami, Emi Nakai, Toshihide Okajima
This paper describes the rational design of a cyclized TEV protease using SpyRing and AlphaFold, resulting in improved thermostability without loss of enzymatic activity.
ACS Omega · Jul 25, 2025Peer-reviewedSynthetic Biology