Stretching the structural envelope of isomeric imatinib analogs that reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP
William J. Netzer, Anjana Sinha, Mondana H. Ghias, Emily Chang, Katherina Gindinova, Emily Mui, Ji-Seon Seo, Subhash C. Sinha
The paper investigates how structurally diverse imatinib analogs affect APP metabolism similarly, identifying potent isomers for further development.
Frontiers in Chemistry · Oct 8, 2024Peer-reviewedPharmacology & Toxicology