Computational design of sequence-specific DNA-binding proteins
Cameron J. Glasscock, Robert J. Pecoraro, Ryan McHugh, Lindsey Doyle, Wei Chen, Olivier Boivin, Beau Lonnquist, Emily Na, Yuliya Politanska, Hugh K. Haddox, David Cox, Christoffer Norn, Brian Coventry, Inna Goreshnik, Dionne K. Vafeados, , David A. Baker
This paper designs sequence-specific DNA-binding proteins computationally and validates them experimentally, achieving high specificity and affinity for target sequences.
Nature Structural & Molecular Biology · Sep 12, 2025Peer-reviewedSynthetic Biology