Accurate strand-specific long-read transcript isoform discovery and quantification at bulk, single-cell, and single-nucleus resolution
Houlin Yu, Christophe H. Georgescu, Akanksha Khorgade, Ghamdan Al‐Eryani, Daniel A. Bartlett, Allison Brookhart, Can Koçkan, James T. Webber, Asa Shin, Emily White, Xylena Reed, Fangle Hu, Sarah Bromberek, Sandra Ndayambaje, Sandeep Aryal, , Aziz M. Al’Khafaji
The paper introduces LRAA, a framework for accurate isoform discovery and quantification in long-read RNA-seq data, outperforming existing methods across multiple benchmarks.
bioRxiv · Feb 12, 2026 · PreprintBioinformatics