Author

Sandeep Aryal

Broad InstituteORCID 0000-0002-1674-4552Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

Clotilde Lagier‐TourenneiD· 2 shared Michael Emmerson WardiD· 2 shared Aaron HeldiD· 1 shared Akanksha KhorgadeiD· 1 shared Allison Brookhart· 1 shared Ana Rita Agra de Almeida QuadrosiD· 1 shared Asa ShiniD· 1 shared Ayub BoulosiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Clotilde Lagier‐TourenneORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program

Matthew Nolan, Sandeep Aryal, I. Sandra Ndayambaje, Maize Cao, Peyton Lee, Moriah J. Hovde, Shuqi Yun, Josette J Wlaschin, Aaron Held, Hortense D. A. M. Beaussant, Benjamin Wymann, Chao-Zong Lee, Su Min Lim, Xin Jiang, Nandini Ramesh, , Clotilde Lagier‐Tourenne

The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.

bioRxiv · Feb 24, 2026 · PreprintNeuroscience

Accurate strand-specific long-read transcript isoform discovery and quantification at bulk, single-cell, and single-nucleus resolution

Houlin Yu, Christophe H. Georgescu, Akanksha Khorgade, Ghamdan Al‐Eryani, Daniel A. Bartlett, Allison Brookhart, Can Koçkan, James T. Webber, Asa Shin, Emily White, Xylena Reed, Fangle Hu, Sarah Bromberek, Sandra Ndayambaje, Sandeep Aryal, , Aziz M. Al’Khafaji

The paper introduces LRAA, a framework for accurate isoform discovery and quantification in long-read RNA-seq data, outperforming existing methods across multiple benchmarks.

bioRxiv · Feb 12, 2026 · PreprintBioinformatics