Novel 3D Mature Osteocyte Perfusion Platform Reveals Subtype-Dependent and Radiation-Sensitive Disruption of Mechanotransduction by Breast Cancer Secretomes
Antonio Salcido-Alcántar, Corrin Bowman, Elaine Goldman, Emma N. Briggs, Anthony M Bierschenk, Tanvi K Rami, William Roy Thompson, Maureen E. Lynch
This study shows that breast cancer subtype and radiation affect osteocyte mechanosensing, with ER+ tumors being more sensitive to radiation-induced secretome changes.
bioRxiv · Oct 23, 2026 · PreprintBioengineering